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Kidney Diseases

Glomerular diseases are a group of health conditions affecting the kidney’s small structure that is crucial in filtering waste and excess fluids from the blood (called the glomerulus, a tiny filter like a spaghetti sieve – each kidney has approximately 1 million of them).
Various factors, including infections, autoimmune disorders, and inherited genetic mutations, can cause these diseases.

Symptoms of glomerular diseases may include swelling, protein in the urine (foamy urine), high blood pressure, and decreased kidney function. These conditions can be serious and may lead to kidney failure if not treated promptly and appropriately.

When inflammation is part of the disease presentation, we refer to it as glomerulonephritis (GN). Examples include post-strep glomerulonephritis, lupus nephritis, IgA nephropathy, and others.
Sometimes, there is no inflammation. For example, one of the most common causes of glomerular diseases is due to diabetes. In this condition, damage to the tiny filters (glomerulus) occurs without direct inflammation. Other examples include Alport syndrome, membranous nephropathy, minimal change disease, focal segmental glomerulosclerosis (FSGS), and others.

The injury to the kidney (and the glomerulus) from inflammation or many other possible causes can lead to scarring and damage to the glomeruli, leading to problems with the kidneys’ ability to filter waste and excess fluids from the blood.

Treatment may include medications to reduce inflammation and control blood pressure and lifestyle changes to protect the kidneys. In severe cases, kidney replacement therapy, such as dialysis or kidney transplant, may be necessary.

Alport Syndrome

By: Tejwinder Sandhu & Vineel Kumar

Alport syndrome is caused by genetic disorders affecting the kidneys, ears, eyes, and the vasculature...

Chronic Kidney Disease

By: Tejwinder Sandhu/ AK

When kidneys become unhealthy over time, it can lead to chronic kidney disease (CKD). There are many causes of CKD...

FSGS (Focal Segmental Glomerulosclerosis)

By: Tejwinder Sandhu

Focal segmental glomerulosclerosis (FSGS) is a collection of many types of kidney disorders characterized by...

IgA Nephropathy

IgA nephropathy is a kidney disease that occurs when abnormal IgA proteins are produced by the body...

IgA Vasculitis

By: Vineel Kumar, Tejwinder Sandhu

IgA vasculitis, formerly Henoch-Schonlein purpura, is the most common childhood systemic vasculitis (inflammation...

Introduction to Kidney Diseases

Glomerular diseases are a group of health conditions affecting the kidney’s small structure that is crucial in filtering waste...

Lupus Nephritis

By: Vineel Kumar

Lupus nephritis is a kidney disorder that occurs as a result of systemic lupus erythematosus (SLE), an autoimmune disease...

Membranous Nephropathy

By: Tejwinder Sandhu & Victoria Vera

Membranous nephropathy is an autoimmune disease in which the body’s immune system targets and attacks...

Minimal Change Disease

By: Victoria Vera/ Tejwinder Sandhu

In the kidneys, the filters (glomeruli) are responsible for cleaning the blood by filtering out waste while keeping...

Nephrotic Syndrome

By: Vineel Kumar

Nephrotic syndrome is defined by abnormal loss of protein through the kidneys into the urine (greater than 3.5 grams per day...

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